SAM-e

What is SAM-e? S-Adenosyl Methionine (SAMe) is an amino acid. SAMe was discovered in 1952 in Italy, where it is manufactured. Until recently, it was exceedingly expensive to produce, and therefore unavailable to the public, although it is fairly well studied. It is manufactured in the brain from another amino acid, methionine. SAM-e is the most active methyl-donor in your body, meaning it donates methyl groups to other chemical compounds in your body including neurotransmitters, changing them into other compounds.

SAMe health benefits:

• Enhances a low mood. Supplementation with SAM-e increases levels of serotonin, dopamine and phosphatides, and improves serotonin and dopamine receptor site binding. Interestingly, treatment with antidepressant drugs that results in improved mood usually also results in increased levels of SAMe, regardless of the drug used.
• Relieves osteoarthritis pain. SAM-e plays an important role in cartilage formation and repair. Stimulates the production of cartilage. Helps reduce morning stiffness.
• Helps with liver disease. SAMe improves intrahepatic cholestasis (cholesterol deposits in the liver, including intrahepatic cholestasis of pregnancy) and reduces serum bilirubin levels.

Precautions & Possible Side Effects:

• Sam-e side-effects include nausea and vomiting in some people, so it is recommended that supplementation be graduated.
• People suffering from bipolar disorder should not take SAM-e, as its rapid antidepressant effects can lead to manic episodes.
• If you plan on taking SAM-e, you would be well advised to supplement with B vitamins also. This will ensure good results and prevent homocysteine build-up.