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Nitric Oxide, NO2 Supplements

What is Nitric Oxide?

Nitric oxide is a gas with a chemical formula NO. It is highly reactive. It participates in many chemical reactions.
Nitric Oxide is created in the body by breaking down the amino acid Arginine. It is an important signaling molecule in the body of mammals including humans, one of the few gaseous signaling molecules known.

NO causes vasodilation (an expansion of the internal diameter of blood vessels), which in turn leads to increased blood flow, oxygen transport, delivery of nutrients to skeletal muscle, and a reduction in blood pressure.

Functions & Health Benefits

  • NO relaxes the smooth muscle in the walls of the arterioles. Nitroglycerine, which is often prescribed to reduce the pain of angina, does so by generating nitric oxide, which relaxes the walls of the coronary arteries and arterioles.
  • The vasodilation effect nitric oxide helps protect the blood vessels from dangerous constriction. This increases the blood vessel flexibility to blood can circulate at a lower pressure.
  • Release of Nitric oxide around the glomeruli of the kidneys increases blood flow through them thus increasing the rate of filtration and urine formation.
  • NO is also responsible for the relaxation of blood vessels in the penis, causing the blood to pool which produces an erection. The prescription drugs Viagra, Levitra and Cialis work in much the same way.
  • NO reduce inflammation. The NO produced by NOS-3 inhibits inflammation in blood vessels. It does this by blocking the exocytosis of mediators of inflammation from the endothelial cells.
  • NO is an important non-adrenergic, non-cholinergic (NANC) neurotransmitter in various parts of the gastrointestinal tract. It causes relaxation of the gastrointestinal smooth muscle. In the stomach it increases the capacity of the fundus to store food/fluids.
  • Nitric oxide serves as a neurotransmitter between nerve cells.
  • NO aids in the killing of engulfed pathogens (e.g., bacteria) within the lysosomes of macrophages.

Nitric Oxide & NO2 Supplements in Bodybuilding

NO2 supplements contains A-AKG (arginine alpha-ketoglutarate) and A-KIC (arginine-ketoisocaproate), natural myodilators that may help boost nitric oxide levels in your body, thereby increasing blood flow, oxygen transport, and delivery of nutrients to skeletal muscle. Nitric Oxide helps with a sustained blood pump in your body. The blood vessels that deliver muscle building agents (nutrients, creatine) to your muscles are “forced open” for an extended period of time throughout the day. This means quicker recovery, enhanced muscle gains, greater strength, more endurance due to the prolonged pump NO2 provides.

NO2 supplements give bodybuilders the ability to build muscle virtually round the clock. NO2 triggers the body's muscle-building "cell-signaling" mechanism by creating a continuous supply of the "cell-signaling" molecule nitric oxide present in the skeletal muscles. When nitric oxide is present in the muscles, it activates "gene-expression" and "turns on" the body's muscle-building mechanism (protein synthesis).

Increasing Nitric Oxide levels can deliver continuous muscle-enhancing benefits:

  • Increased muscle growth
  • Greater strength
  • Better muscle recovery
  • Increasing endurance
  • Improvement in stamina


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April 10, 2020